Frosinone (Italian pronunciation: [froziˈnoːne] (listen), local dialect: Frusenone) is a town and comune in Lazio, central Italy, the administrative seat of the province of Frosinone. It is located about 75 kilometres (47 mi) south-east of Rome close to the Rome-Naples A1 Motorway. The city is the main city of the Valle Latina ("Latin Valley"), an Italian geographical and historical region that extends from south of Rome to Cassino.

Until the 19th-century, it was a village with a rural vocation, while from the twentieth century it became an important industrial and commercial center. Traditionally considered a Volscian city, with the name of Frusna and then the Roman of Latium adiectum as Frùsino, over the course of its millenary history it has been subjected to multiple devastations and plunders caused by its geostrategic position; as a consequence of this, as well as due to the destruction due to seismic events (the most ruinous of which occurred in September 1349), it retains only rare, albeit significant, traces of its past.